地佐辛与布托啡诺在腹腔镜阑尾切除术后预镇痛中的应用比较

Comparative efficacy and safety of dezocine and butorphanol in patients undergoing laparoscopic appendectomy

目的：比较地佐辛和布托啡诺在腹腔镜阑尾切除术后预镇痛中的疗效及安全性.方法：选择ASAⅠ～Ⅱ级腹腔镜阑尾切除术患者80例,按双盲法随机分为A组、B组两组,各40例,A组为地佐辛静脉注射组,B组为布托啡诺静脉注射组.结果：在术后镇痛中,A组的患者苏醒迅速,血流动力学稳定,Ramsay评分RSS镇静满意,NRS镇痛良好,不良反应少,优于布托啡诺.结论：地佐辛用于腹腔镜阑尾切除术后镇痛,患者苏醒迅速、平稳,不良反应少,镇痛持续时间长,比布托啡诺镇痛效果更满意,安全性更高.

Objective To evaluate the comparative efficacy and safety of Dezocine and Butorphanol in patients undergoing laparoscopic appendectomy. Methods A total of 80 patients( ASA I or II) scheduled for laparoscopic appendectomy were randomly assigned into intravenous dezocine group( group A,n = 40) or intravenous Butorphanol group( group B,n = 40). Results After operation,compare with group B,the recovery of consciousness in group A was quicker and the hemodynamics of patients was more stable. The satisfactory rate of sedation and analgesia in group A were higher than group B. Furthermore,the group A had less adverse effect. Conclusion These results demonstrate that the patients not only regain consciousness quickly and steadily,but also have a long duration of analgesia by Dezocine undergoing laparoscopic appendectomy. Compare with Butorphanol,Dezocine can provide more satisfactory postoperative analgesic effect and higher safety.