小剂量雷公藤多甙治疗复发性口疮对免疫功能的调节作用

Study on lmmune Regulation of Low dose of Glycosides of Radix Tripterygii in Treatment of Recurrent Aphthous ulcer

目的 :探讨复发性口疮患者免疫状态的改变及小剂量雷多藤公甙等药物对患者免疫功能的影响。方法 :选择复发性口疮患者 10 0例作为观察组Ⅰ ,予以小剂量雷公藤多甙 ,复方丹参 ,锌、铁制剂口服。观察组Ⅱ ,30例 ,只接受复方丹参 ,锌、铁制剂治疗。检测服药前及服药两月后T淋巴细胞亚群水平 (APPAP法 )和血清免疫球蛋白、补体C3、C4(免疫透射比浊法 ) ,循环免疫复合物 (沉淀比浊法 )含量。结果 :①观察组Ⅰ、观察组Ⅱ与对照组比较 ,CD3、CD4百分值 ,CD4/CD8比值和C3含量显著降低 ,CD8、IgG、CIC含量显著升高 (P <0 .0 1)。②观察组Ⅰ治疗前、后对比 ,CD3、CD4、CD8、CD4/CD8及IgG、C3、CIC与对照组对比有显著性差异 (P <0 .0 1) ,观察组Ⅰ、观察组Ⅱ对比 ,含雷公藤多甙治疗组对改善免疫功能较不含雷公藤多甙治疗组对改善免疫功能为优 ,两者免疫检测指标有显著差异 (P <0 .0 1)。结论 :证实了复发性口疮的发病与免疫功能紊乱密切相关 ,小剂量雷公藤多甙等治疗RAU可有效调节及恢复患者细胞免疫、体液免疫功能。

Objective: In order to study the changes of immune status of patients with rucurrent aphthous ulcer (RAU) and the effect of low dose of glycosides of Tripterysium wilfordii on patients' immune function. Methods: 100 patients with RAU were selected as the experiment group Ⅰ and treated with low dose of glycosides of Tripterygium wilfordii and compound Danshen, Zinc and Ferradia oral liquid. 30 patient with RAU as the experiment group Ⅱ were treated only with Compound Danshen, Zinc and Ferralia Oral Liquid. The level of T lymphocyte subgroup (APPAP method), the contents of serum immunoglobulin, complement C3 and C4 (immune transmission turbidity method), and circulation immune complex (precipitin turbidity method) of all patients were determined when the patients took medicines before and after two months. Results: (1) As compared with the control group, CD3 and CD4 percen values, CD4/CD8 ratio and C3 content of two experiment groups were obviously decreased, CD8, IgG and CIC contents were raised ( P <0.01). (2) The comparison of before and after treatment of the experiment group Ⅰ indicated that CD3、CD4,CD8,CD4/CD8, IgG, C3 and CIC showed a significant differences ( P <0.01). The comparison of two experiment groups indicated that group Ⅰ was better than group Ⅱ in the hand of improving immune reaction. There was significant difference from immune detection markers and the two groups ( P <0.01). Conclusion: These results bear out that the attack of RAU is closely linked to the disturbance of immune reaction, and low dose of glycosides of Radix Triptergii can effectively regulate and recover cellular and humoral immune responses of patients with RAU.