双分子层脂膜嵌入克霉唑前后的电化学性质研究

A Study on Electrochemical Properties of Bilayer Lipid Membrane Intercalated with Clotrimazole

报道了抗真菌药克霉唑与人工脂膜的相互作用 ,试图阐明该药的分子生物学的作用基础 .用注射方法分别制备 3种双分子层脂膜 (BLM ) ,并运用循环伏安法测量了修饰物克霉唑加入前后人工双分子层脂膜的电性质 .结果发现克霉唑可显著降低膜电阻并证实该药确能改变人工双分子层脂膜的通透性 .

In this paper interactions of bilayer lipid membrane with clotrimazole as the antifungal agent were reported in order to interpret the action basis about the molecularbiology of this drug.Using the injecting method, we prepared three bilayer lipid membranes(BLM) respectively,and by the cyclic voltammetry method we determined properties of BLM before and after adding clotrimazole into the membranes.It was found that clotrimazole could remarkably reduce the membrane resistance and demonstrated that the drug as an antifungal substance might certainly change the permeability of bilayer lipid membrane.