摘要
研究了新型哒嗪酮类化合物 96 12对家兔和大鼠血小板聚集的影响 .结果发现 ,96 12在体外能明显抑制花生四烯酸 (AA) ,腺苷二磷酸 (ADP)和凝血酶 (thrombin)诱导的家兔血小板聚集 ,其IC50 分别为 3 2 0 ,9 44和 7 10 μmol/L .96 12 .灌胃给药 (ig) ,能显著抑制AA和ADP诱导的大鼠血小板聚集 ,其作用与同等剂量 (15 0mg/kg)的阿斯匹林 (ASA)相比无明显差异 (P >0 0 5 ) .
This paper has revealed the effects of a novel pyridazinone(9612)on the platelet aggregation of rabbits and rats.In the platelet-rich plasma of rabbits,9612 remarkably inhibited platelet aggregation induced by arachidonic acid(AA),adenosine-5-diphosphate(ADP)or thrombin in vitro ,with the IC 50 values of 3 20,9 44 or 7 10 μmol/L respectively.9612(ig) was also able to inhibit the rat platelet aggregation induced by AA or ADP;Compared with equivalent dosage of saspirin(ASA)there was no significant difference( P >0 05).It is showed that 9612 is an effective platelet aggregating inhibitor,its mechanism needs to be investigated further.
出处
《沈阳药科大学学报》
CAS
CSCD
2000年第6期441-443,共3页
Journal of Shenyang Pharmaceutical University
关键词
哒嗪酮类化合物
血小板聚集
AA
ADP
凝血酶
pyridazinone
platelet
platelet aggregation
arachidonic acid
adenosine-5-diphosphate
thrombin.
