血清瘦素水平与冠心病危险分层及冠脉病变程度的相关性

Correlation between serum leptin level with coronary heart disease risk stratification and lesion degree of coronary artery

目的观察不同危险分层冠心病患者血清瘦素(leptin)水平的变化,探讨血清leptin浓度与冠脉病变程度和冠脉Gensini评分的相关性及其在冠心病危险分层中的价值。方法 120例研究对象分为4组,分别为非冠心病组,稳定性心绞痛(SAP)组,不稳定性心绞痛(UAP)组及心肌梗死(AMI)组,检测并分析各组leptin水平与冠心病危险因素、危险评估生化标志物的相关性。结果 AMI组血清leptin水平显著高于非冠心病组和SAP组,leptin水平随着冠脉病变程度及Gensini积分的增加有逐步上升趋势,并与常用冠心病危险分层指标心肌肌钙蛋白、吸烟指数呈线性正相关,与血尿酸呈负相关。结论 leptin水平可作为评估急性冠脉事件发生有价值的标志物,并与常用冠心病危险分层生化标志物及冠脉病变程度具有较好的相关性。

Objective To observe the change of serum leptin in different risk stratifications of coronary heart disease（CHD） and to investigate its relationship with the severity of coronary artery lesion and the coronary artery Gensini score and its value in the coronary heart disease risk stratification. Methods According to coronary angiography,120 research subjects were enrolled and di- vided into 4 groups：the non-CHD group, stable angina（SAP） group, unstable angina pectoris（UAP） group and myocardial infarc tion group（AMI）,respectively. The serum leptin levels in 4 groups were determined by immunoassay and the correlation between the leptin level with the coronary heart disease risk factor and biochemical markers of risk assessment was analyzed. Results The serum leptin level in the AMI group was significantly higher than that in the non-CHD group and the SAP group, the leptin level showed the increasing trend with the increase of the coronary lesion severity and the Gensini scores and was positively related with the CHD risk stratification indicators cTnT and smoking index,and negatively related with blood uric acid. Conclusion The serum leptin may be used as the valuable marker for evaluating the occurrence of acute coronary event and has good correlation with usual biochemical markers of CHD risk stratification and the severity of coronary artery lesion.