血清同型半胱氨酸和巨噬细胞移动抑制因子水平与颈动脉粥样硬化相关性研究

Study on correlation between serum Hcy and MIF with carotid atherosclerosis

目的探讨血清同型半胱氨酸(Hcy)、巨噬细胞移动抑制因子(MIF)水平与颈动脉粥样硬化的关系。方法对258例住院和门诊的受试者应用彩超观察颈动脉血管解剖形态、内膜情况、有无斑块、斑块回声性质,测量颈动脉内膜-中膜厚度(IMT),依据检查结果分为3组:对照组、增厚组、斑块组。斑块组依据斑块的回声特点分为2组:稳定斑块组、不稳定斑块组。同时对受试者测定血清Hcy、MIF水平及生化指标测。比较组间血清Hcy、MIF水平的差异,计算血清Hcy水平、MIF水平、IMT三者之间相关系数。结果对照组、增厚组、斑块组血清Hcy、MIF水平依次升高,各组间比较差异有统计学意义(P<0.01);血清Hcy、MIF水平不稳定斑块组明显高于稳定斑块组,差异有统计学意义(P<0.01)。血清Hcy水平、血清MIF水平、IMT三者之间呈正相关(r=0.584、0.562、0.607,P<0.01)。结论血清Hcy、MIF水平与颈动脉粥样硬化的程度和斑块稳定性密切相关,Hcy可能通过MIF导致动脉粥样硬化的形成。

Objective To investigate the correlation between serum homocysteine（Hcy） and macrophage migration inhibitory factor（MIF） with carotid atherosclerosis and between serum Hcy and MIF,and to study whether serum Hcy influence the carotid atherosclerosis formation by MIF. Methods 258 inpatients and outpatients were performed the color ultrasound examination to ob serve the carotid arterial vascular anatomic form, endomembrane circumstance, plaque and the plaque echo nature, and the carotid in- tima media thickness（IMT） was measured. According to the results of color ultrasound,the cases were divided into three groups： IMT normal group（control group）, thickening group and plaque group. According to the plaque echo characteristics, the plaque group was redivided into two subgroups：stable plaque group and unstable plaque group. Serum Hcy and MIF levels and biochemical parameters were measured simultaneously in all cases. The differences of serum Hcy and MIF levels were compared between groups. The correlation coefficients among serum Hcy levels, MIF levels and IMT were calculated. Results The serum Hcy and MIF levels in the control group, thickening group and plaque group were increased in turn, the difference among groups was statisti- cally significant（P^0.01）;which in the unstable plaque group was significantly higher than that in the stable plaque group, the difference between them was statistically significant（P〈0.01）. The positive correlation was found among serum Hey levels, serum MIF levels and 1MT（r=0. 584,0. 562,0. 607,P〈0.01）. Conclusion The serum Hcy and M1F levels are closely related with the carotid atherosclerosis degree and the plaque stability; the serum Hcy and MIF levels are positively correlated with the carotid arte rial IMT;serum Hey is positively correlated with the MIF level, Hcy may cause the carotid atherosclerosis formation via MIF.