应用低剂量骨水泥注入治疗骨质疏松性压缩骨折的临床研究

Clinical study of low-dose bone cement injection for treating osteoporotic compression fractures

目的探讨椎体成形术中低剂量骨水泥注入在治疗骨质疏松性压缩骨折术中的疗效。方法对2009年2月至2012年2月收治的41例骨质疏松性压缩骨折患者进行经皮椎体成形术,将患者按照骨水泥注入量分为小剂量组和常规剂量组,并对术后视觉模糊评分(VAS)、骨水泥渗漏率、椎体高度恢复程度、相邻节段椎体继发骨折发生率进行观察、评估、对比。结果经过3~15个月随访,平均11.2个月,常规剂量组与小剂量组在术后疼痛缓解方面效果相当,但在椎体高度恢复率方面,常规剂量组要优于小剂量组,在骨水泥渗漏率及相邻节段椎体继发骨折发生率方面,小剂量组要优于常规剂量组。结论椎体成形术操作过程中,应用注入低剂量骨水泥方法,在达到满意临床效果同时,可以有效地减少骨水泥渗漏、相邻节段继发骨折等并发症发生率。

Objective To explore the clinical effect of low-dose bone cement injection in percutaneous vertebroplasty for treating osteoporotic vertebral compression fractures. Methods 41 cases of osteoporotic vertebral compression fractures from February 2009 to February 2012 were treated with percutaneous vertebroplasty. The patients were divided into the low-dose group and the conventional dose group according to the amount of bone cement injection. The postoperative VAS score, cement leakage rate, verte- bral height restoration degree and incidence rate of adjacent segment fracture were observed,evaluated and compared. Results The follow-up period ranged from 3 months to 15 months（average 11.2 months）. The postoperative pain relief effect in the conventional dose group and the low dose group was similar. The vertebral height restoration rate of the conventional dose group was superior to that of the low-dose group. In the aspects of the bone cement leakage rate and adjacent segment vertebral secondary fracture, the low-dose group was superior to the conventional dose group. Conclusion In the procedure of percutaneous vertebroplasty,applying the low-dose bone cement injection can reach the satisfactory clinical effect,at same time can effectively reduce the complication oe currenee rate of bone cement leakage and adiaeent segments secondary fractures.