扬州地区体检人群血脂与尿酸异常率及相关性分析

Abnormity rates of blood lipids and uric acid and their relationship analysis in health examination population in Yangzhou city

目的研究扬州地区18岁以上体检人群血脂与尿酸的异常率及相关性。方法选取2011年10月至2012年8月在江苏省苏北人民医院体检中心接受检查的28 202名体检者为研究对象,检测其血清中总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)及尿酸的水平。分析各项指标异常率及与其年龄、性别的关系,分析尿酸和血脂二者之间的关系。结果受检人群中,TG、TC、LDL-C、HDL-C异常率及高尿酸血症患病率分别为31.5%、32.1%、18.4%、15.9%、17.3%,男性高于女性(P<0.05)。血脂异常率50岁之前随年龄增长而增长,>50~70岁血脂异常的检出率最高,70岁之后逐渐下降;高尿酸血症患病率随年龄升高逐渐升高。高尿酸血症组的血脂异常率较正常尿酸组高(P<0.01)。结论扬州地区18岁以上体检人群血脂、尿酸异常率较高,且与年龄、性别存在显著关系;尿酸升高与血脂代谢异常有一定的相关性。血脂、尿酸均为心脑血管疾病的危险因素,合理的饮食结构和定期体检对预防此类疾病的发生有重要意义。

Objective To investigate the abnormity of blood lipids and uric acid, and to analyze their relationship in health exami nation population over 18 years in Yangzhou. Methods ＂I＇otally 28 202 individuals receiving the health examination from October 2011 to August 2012 in the physical examination center of this hospital were enrolled in our study. Total cholesterol（TC） ,triglycer ide（TG） ,low density lipoprotein cholesterol（LDL-C）, high density lipoprotein cholesterol（HDL-C） and blood uric acid（UA） were detected,and the relationship between age and sex with the ahnormity of blood lipids and uric acid and the relationship between UA levels and blood lipids were analyzed. Results Among the detection population,the detection rates of abnormal TG,abnormal TC, abnormal HDL-C,abnormal LDL-C and hyperuricemia were 31.5~/oo, 32. 1~, 15. 9%, 18.4~ and 17. 3~/oo respectively. Compared with females,males had the higher rates of abnormal blood lipids and UA（P^0. 05）. The rate of abnormal blood lipids was in- creased with age increase before 50 years old, the i〉50--70 years old group had the highest abnormity rate of blood lipids, then which was gradually decreased after 70 years old. The morbidity rate of hyperuricemia was increased with age. Compared with nor- mal UA group,the hyperuricemia group had the higher rate of abnormal blood lipids（P%0.01）. Conclusion The health examina- tion population over 18 years have the higher abnormity rate of blood lipids and uric acid,which is significantly correlated with age and sex; the increase of uric acid has certain correlation with abnormal blood lipids metabolism. Both blood lipids and uric acid are the risk factors of cardiocerebralvascular diseases, rational dietary structure and periodic physical examination have the important significance to prevent the occurrence of these diseases.