湖南地区早发冠心病血瘀证临床流行病学研究

The Clinical Epidemiological Study of Premature Coronary Artery Disease with Blood Stasis in Hunan Region

目的调查早发冠心病（PCAD）血瘀证证患者相关危险因素及各亚型证型特征。方法对322例早发冠心病患者进行临床流行病学调查，并应用秩和检验，Logistic回归分析等方法对资料分析研究。结果PCAD血瘀证存在明显的脂类代谢异常，其比晚发冠心病血瘀证存在更显著的脂类代谢和血流变异常；BMI、吸烟、TG、LDL、高血压是PCAD血瘀证的危险因素；血瘀证各亚型血瘀证积分，从高到低依次是痰浊血瘀证，气虚血瘀证，气滞血瘀证，阴虚血瘀证（P〈0．05）；早发冠心病血瘀证各亚型中，0～1年病程以痰浊血瘀为主，2～5年病程以气滞血瘀居多，5年以上病程以气虚、阴虚血瘀为主（P〈0．01）。结论血瘀证存在明显的脂类代谢异常，且PCAD血瘀证比晚发冠心病血瘀证存在更显著的脂类代谢和血流变异常；BMI、吸烟、TG、LDL、高血压是PCAD血瘀证的危险因素。

Objective： To investigate the relevant risk factors and differentiation subtypes of symptoms of the blood stasis of premature coronary artery disease. Methods： Information of 322 patients with premature coronary artery disease were epidemically investigated,and using rank-sum test.Logistic regression analysis to analysis the results. Results： There was obvious abnormal lipid metabolism state in the blood stasis of premature coronary artery disease;The abnormal lipid metabolism and hemorheology of the premature coronary artery disease with blood stasis are more significant than the late coronary artery disease with blood stasis. BMI, smoking,TG, LDL, high blood pressure were risk factor PCAD with blood stasis.Blood stasis syndrome integral of each subtypes from high to low was： phlegm turbid blood-stasis syndrome,deficiency and blood-stasis syndrome,stagnation and blood-stasis syndrome,Yin deficiency and blood-stasis syndrome.In each subtypes of premature coronary artery disease, course less than 1 year was maily phlegm turbid blood-stasis syndrome, course 2-5 years was maily stagnation and blood-stasis syndrome, course above 5 years was maily deficiency and blood-stasis syndrome, Yin deficiency and blood-stasis syndrome. Conclusion： There is obvious abnormal lipid metabolism state in the blood stasis of premature coronary artery disease,and the abnormal lipid metabolism and hemorheology of the premature coronary artery disease with blood stasis are more significant than the late coronary artery disease with blood stasis. Also, BMI, smoking, TG, LDL, high blood pressure are risk factor PCAD with blood stasis.