杀菌剂肟菌酯的合成工艺

Synthesis process of trifloxystrobin

以邻甲基苯乙酸为起始原料,经过氧化、酯化、肟化及溴代反应,最后与间三氟甲基苯乙酮肟缩合制备了杀菌剂肟菌酯.每步的反应产物均通过1 H NMR确认,总收率为17%.本工艺路线采用廉价的起始原料降低了生产成本,反应条件温和且易于控制,各步收率较高,有进一步研究与应用价值.

Trifloxystrobin was synthesized with a new method which adopted 2-methyl phenylacetate as the starting material through partial oxidation, esterification, oximation, bromization and condensation finally with 3＇-（trifluoromethyl） acetophenone oxime. The reaction products of each step were confirmed by 1H NMR. The total yield was about 17%. The process route uses inexpensive starting materials, and reaction conditions are mild and easy control with good yield of each step, which is worthy of further study.