东革阿里化学成分的分离与鉴定

Isolation and identification of chemical constituents from Eurycoma longifolia Jack.

目的研究东革阿里（Eurycoma longifolia Jack．）的化学成分。方法采用硅胶吸附柱色谱、Sephadex LH-20柱色谱、开放ODS柱色谱、高效液相色谱和反复重结晶等手段进行分离纯化，并通过理化性质与光谱分析方法鉴定了化合物的结构。结果分离鉴定了8个化合物，分别为东莨菪素（scopoletin，1）、9-甲氧基-铁屎米-6-酮（9-methoxycanthin-6-one，2）、laurycolactone A（3）、eurylene（4）、β-carboline-1-propionicacid（5）、3β-羟基豆甾-5，22-二烯-7-酮（3β-hydroxy-stigmast-5，22-dien-7．one，6）、13β，21-dihydroxyeurycomanone（7）和iandonol（8）。结论化合物5-7为首次从Eurycoma属植物中分离得到，化合物8为首次从东革阿里植物中分离得到。

Objective To study the chemical constituents of Eurycoma longifolia Jack. Methods The com- pounds were isolated by chromatography on silica gel column, Sephadex LH- 20 column, ODS column, HPLC and recrystaUization methods, and their structures were determined on the basis of special analysis. Results Eight compounds were obtained and identified as scopoletin （1）, 9-methoxycanthin-6-one （2）, laurycolactone A （ 3 ）, eurylene （ 4 ） ,β-carboline-1-propionic acid （ 5 ）, 3β-hydroxy-stigmast-5,22-dien-7 -one （6）, 13β,21-dihydroxyeurycomanone （ 7 ） and iandonol （ 8 ）. Conclusions Compounds 5- 7 are isolated from Eurycoma for the lust time, compound 8 is separated from Eurycoma longifolia Jack. for the first time.