宁波市某火力发电厂员工免疫功能检测结果分析

Test result analysis on the immune function of workers of a power plant in Ningbo City

[目的]探讨长期职业暴露对发电厂员工免疫功能的影响。[方法]采用美国BD公司的FACSCalibur流式细胞仪检测技术和免疫比浊法,对200例发电厂员工(暴露组)和80例正常健康体检人员(对照组)的细胞免疫和体液免疫功能进行检测分析。[结果]暴露组免疫球蛋白异常率为16.5%,高于对照组的7.5%(P<0.05)。CD3、CD4、CD8和CD4/CD8值均明显低于对照组(P<0.05)。暴露组外周血清中免疫球蛋白IgG、IgA的含量降低,与对照组相比,差异有统计学意义(P<0.05)。[结论]长期发电厂环境下的职业暴露,T淋巴细胞亚群CD3、CD4、CD8和CD4/CD8值可能会降低,体液免疫功能也可能会降低。

Abstract ： I Objective ] To investigate the effect of long term occupational exposure on the immune function of workers of a power plant. [ Methods ] An exposure group of 200 workers in a power plant and a control group of 80 normal people of health checkup were examined for their cellular immunity and humoral immunity by flow cytometry instrument testing technology of the United States BD company and immune turbidimetric method. [ Results] The abnormality rate （ 16.5% ） of immune globulin in exposure group were significantly higher than that （7.5%） in control group （ P 〈 0.01 ）. The values of CD3, CD4, CD8 positive T- lymphocytes and the ratio CD4/CD8 were significantly lower in exposure group than those in control group （ P 〈 0.05 ）. The levels of IgG and IgA in exposure group were significantly lower than those in control group （ P 〈 0.05 ）. [ Conclusion] k is indicated that long term occupational exposure in power plant may lower the values of CD3, CD4, CD8 positive T - lymphocytes and the ratio of CD4/CD8 and reduce the function of humoral immunity.