中西医结合治疗咽喉反流病的临床效果观察

Clinical curative effect of traditional Chinese combined with Western medicine in the treatment of pharyngeal reflux disease

目的观察雷贝拉唑联合柴胡疏肝散治疗咽喉反流病的临床效果。方法选取2010年1月至2012年12月于浙江中医药大学附属同德医院接受治疗的咽喉反流病患者110例，完全随机分为对照组和观察组，每组55例。对照组给予雷贝拉唑治疗，每次10mg，每日早、晚餐前30min口服；观察组在对照组基础上加用柴胡疏肝散，每日1剂，水煎服，分2次服用。观察比较2组患者治疗前后的内窥镜检查评分及临床效果。结果2组治疗后内窥镜检查评分与治疗前比较[观察组：（0．2±0．1）分比（1．5±0．6）分；对照组：（0．3±0．1）分比（1．5±0．7）分]，差异均有统计学意义（均P〈0．05）。治疗后，观察组内窥镜检查评分明显低于对照组，差异有统计学意义（P〈0．05）。对照组总有效率为70．9％（39／55），明显低于观察组的90．9％（50／55），差异有统计学意义（p〈0．05）。结论采用雷贝拉唑联合柴胡疏肝散治疗咽喉反流病临床效果明显。

Objective To observe the clinical effect of rabeprazole thiazole combined with Bupleurum Liver-Coursing Decoction on pharyngeal reflux disease. Methods All 110 patients with pharyngeal reflux disease in Tongde hospital of Zhejiang province from January 2010 to December 2012 were selected and randomly divided into control group （55 cases） and observation group, （55 cases）. The control group was given rabeprazole thiazole and the observation group was given rabeprazole thiazole combined with Bupleurum liver-coursing decoction. Endoscopy results and clinical effect of two groups were observed and compared. Results There were significant differences on endoscopy results of two groups after treatment compared with before treatment [ observation group： （0.2 ± 0.1 ） scores vs （ 1.5 ± 0.6） scores ; control group ： （0.3 ± 0.1 ） scores vs （ 1.5 ± 0.7 ） scores ] （ P 〈 0.05 ）. There were significant differences, on endoscopy results of observation group after treatment compared with control group （ P 〈 0.05 ）. The total effect rate of control group was 70.9% （39/55）, which was significantly lower than that of obServation group 90.9% （50/55） （P 〈 0. 05 ）. Conclusion Rabeprazole combined with Bupleurum liver-coursing Decoction has a good clinical effect on the treatment of pharyngeal reflux disease.