摘要
目的探讨地佐辛对鞘内舒芬太尼分娩镇痛所致瘙痒的治疗作用。方法选取90例美国麻醉师协会分级I-Ⅱ级、单胎、足月（≥37周）、枕前位妊娠拟经阴道分娩，行鞘内注射舒芬太尼5ug分娩镇痛后24h内瘙痒的产妇，完全随机分成2组（每组45例）。地佐辛组静脉注射地佐辛5mg（1m1），0．9％氯化钠注射液组静脉注射0．9％氯化钠注射液1ml。瘙痒评分、镇痛评分、镇静评分每5分钟记录1次，记录30min。结果地佐辛组瘙痒的治疗有效率明显高于0．9％氯化钠注射液组[80．0％（36／45）比15．6％（7／45），P〈0．01]，2组的镇痛评分比较差异无统计学意义[（2．2±0．5）分比（2．0±0．3）分]（P〉0．05），2组的镇静评分比较差异有统计学意义（P〈0．05）。结论地佐辛5mg静脉注射可以有效地治疗鞘内舒芬太尼分娩镇痛所引起的瘙痒。
Objective To investigate the effect of dezocine on the spinal sulfentanyl-induced pruritus during labor analgesia. Methods Ninety patients with american society of anesthesiologists physical status 1-2, nulliparous and undergoing a spontaneous labor （ ≥37 weeks of gestation ） with a live, singleton fetus, receiving spinal sulfentanyl-induced pruritus during labor analgesia （ in postoperative 24 h ） were randomly allocated to receive 5 mg dezocine （1 ml） （dezocine group, 45 cases）or 1 ml 0.9% sodium chloride injection （0.9% sodium chloride injection group, 45 cases）intravenously. Pruritus, sedative and the level of postoperative pain were assessed every 5 min till the end of the study period （30 min）. Results The treatment success rate in the dezocine group was higher than that in the 0.9% sodium chloride injection group [ 80.0% （36/45） vs 15.6% （7/45）, P 〈 0.01 ]. Other side effects, such as decreased analgesia, were not significantly different between groups. Sedation scores between the two groups was statistically significant [ （ 2. 2 ± 0. 5 ） scores vs （ 2. 0 ± 0. 3 ） scores ]. Conclusion Dezocine is an efficient drug treatment for spinal sulfentanyl-induced pruritus during labor analgesia.
出处
《中国医药》
2014年第1期109-111,共3页
China Medicine
关键词
分娩
镇痛
地佐辛
舒芬太尼
瘙痒
Labor
Analgesia
Dezocine
Sulfentanyl
Pruritus
