摘要
新生儿脑损伤可继发多种神经系统并发症,是新生儿死亡的重要原因之一.目前研究发现造血因子促红细胞生成素（EPO）能减轻新生儿脑损伤,对损伤的神经细胞有保护和修复作用,并可能提高远期神经预后.EPO及其受体特异性地分布于胎儿及新生儿脑的不同部位.EPO为神经细胞的存活及发育开辟了新途径,并对新生儿脑损伤的治疗提供了临床应用前景.EPO发挥神经保护作用的主要机制是抗神经细胞凋亡,其在活体内主要通过三条独立的信号通路实现,其他机制还包括抗炎、营养神经、生血管、抗氧化及抗惊厥等.
Brain injury is a significant cause leading to death of neonates with a considerable variety of complications. Up to now researches have found the neuroprotective actions of erythropoietin （EPO） originally identified as erythropoiesis on neonatal brain injury. EPO has been reported to induce a broad effect in the brain directed to protect and repair neurons damage which are likely to contribute to the improvement in long-term neurological functional outcomes. EPO may provide a new approach for promoting survival and growth in nerve cells and hold great promise for the future treatments of neonatal brain injury. EPO and EPO receptor distribute in defferent parts of brain in fetus and newborns. A fundamental mechanism of EPO-induced neuroprotection is its ability to inhibit apoptosis that EPO and EPO receptor have been shown to modulate three cellular signal transduction pathways. The other neuroprotection mechanisms of EPO-induced include anfi-infammatory ,neurot- rophy, anti-oxidation, angiogenesis, promoting neurogenesis and anti-epilepsy.
出处
《国际儿科学杂志》
2014年第1期18-21,共4页
International Journal of Pediatrics
基金
上海市浦东新区卫生系统优秀青年医学人才培养计划（PWRq2011-25）
