内源性二氧化硫：心血管调节的新型气体信号分子

Endogenous sulfur dioxide：a novel gasotransmitter in cardiovascular system

长期以来二氧化硫一直被认为是一种废气,近年来越来越多的研究表明二氧化硫在心血管系统内源性生成,具有重要的心血管生理学效应,并对多种心血管疾病如高血压、动脉粥样硬化等疾病的病理生理学过程具重要的调节意义,成为继一氧化氮、一氧化碳和硫化氢后的又一具心血管调节作用的气体信号分子.该文对内源性二氧化硫在心血管系统的研究现状作一综述.

Sulfur dioxide has been considered as a toxic gas. However, recently more and more studies have shown that sulfur dioxide can be generated endogenously in cardiovascular system and has broad physiolog- ic effects. Studies demonstrate that sulfur dioxide plays an important role in the regulation in the pathophysiologic process of many cardiovascular diseases, such as hypertension, atherosclerosis. These findings suggest that sulfur dioxide might be a novel endogenous gaseous signaling molecule involved in the regulation of cardiovascular functions.