不同时间点测定血浆促肾上腺皮质激素和皮质醇对急性脑梗死的临床意义

Clinical significance of plasma adrenocorticotropic hormone and cortisol of patients with acute cerebral infarction at different time

目的检测急性脑梗死患者在不同时间点的血浆促肾上腺皮质激素(ACTH)和皮质醇(cortisol),观察并分析测定结果,探讨监测血浆促肾上腺皮质激素和皮质醇水平的变化对急性脑梗死的病情判断及预后的临床意义。方法选择该院2010年10月至2011年7月收治的73例急性脑梗死患者作为观察组,另选取70例非急性脑梗死患者作为对照组。采用电化学发光法测定不同时点血浆促肾上腺皮质激素和皮质醇的水平变化,观察并分析两组患者不同时间点的血浆促肾上腺皮质激素和皮质醇的水平变化。结果观察组患者在8:00、16:00和0:00的血浆促肾上腺皮质激素和皮质醇水平均明显高于对照组患者,两组差异具有统计学意义(P<0.05);观察组中,预后好的患者在不同时间点测定的血浆促肾上腺皮质激素和皮质醇水平明显低于预后差的患者,差异有统计学意义(P<0.05)。结论测定不同时间点血浆促肾上腺皮质激素和皮质醇的水平变化,有助于急性脑梗死病情的判断及预后,具有重要的临床意义。

Objective To detect the plasma adrenocorticotropic hormone and cortisol of patients with acute cerebral infarction at different time,and to observe and analyze the results so as to explore the clinical significance on the prognosis of the disease. Meth-ods 73 patients who were treated in the hospital with acute cerebral infarction from October 2010 to July 2011 were selected as the observation group,while another 70 patients without the acute cerebral infarction were selected as the control group. The plasma adrenocorticotropic hormone and cortisol levels were detected at different time by means of the electro-chemiluminescence immuno- assay,then the content changes of plasma adrenocorticotropie hormone and cortisol of patients were observed and analyzed. Results The plasma adrenoeorticotropic hormone and cortisol at 8：00,16：00 and 0：00 o＇clock of patients in the observation group were higher than those of the control group, and there were statistically significant differences between two groups （P〈0.05）. In the ob- servation group,in terms of the levels of plasma adrenocortieotropic hormone and cortisol of patients with acute cerebral infarction patients at different time, the detective results of patients with good prognosis were lower than those of the ones with bad progno- sis,and the differences were statistically significant（P〈0.05）. Conclusion The detection of plasma adrenocorticotropic hormone and cortisol at different time is important for clinical, because it could help to determine the condition and prognosis of acute cerebral infarction.