卵泡的发育和调控机制研究进展

Research Progress of the Folliculogenesis and Its Regulation

静止的始基卵泡激活后经过初级卵泡、次级卵泡的发育阶段到达窦前卵泡阶段,接着窦卵泡族被募集,进一步发育,经过卵泡选择、优势化,最后发育成成熟的排卵前卵泡。该过程复杂,许多不同来源的细胞因子和内分泌激素在不同时间和空间上共同完成。随着分子生物学技术的发展,人们对卵泡发育和调控机制的认识大大提高。然而,卵泡发育的调控机制极其复杂,尤其是始基卵泡的激活机制至今仍不清楚。因此,透彻理解卵泡发育和分子调控机制在转化医学和人类生殖中的临床应用非常重要。

The quiescent primordial follicles, after activated,grow and develop through stages of primary and secondary follicles, and then the antral stage. A cohort of antral follicles are recruited for further growth and dominance. The matured follicle will be ovulated at last. This process is so complicated,which is controlled by a number of different sources of cytokines and endocrine hormones,at different time and space. With the development of molecular biology techniques,many mechanisms of folliculogenesis were uncovered deeply. However,the controlled folliculogenesis is complicated,especially the initiation and activation of primordial follicles. It is very important to understand thoroughly molecular aspects of folliculogenesis for the translational medicine in clinical reproductive medicine.