阿仑膦酸钠与阿法骨化醇治疗老年性骨质疏松症的疗效比较

COMPARED THE EFFICACY OF ALENDRONATE AND ALFACALCIDOL IN TREATMENT OF SENILE OSTEOPOROSIS

目的比较阿仑膦酸钠片、阿法骨化醇胶囊治疗老年性骨质疏松症的临床疗效及安全性。方法将56例老年性骨质疏松症患者,采取随机法分成2组。观察组给予口服阿仑膦酸钠片70 mg,每周1次;对照组给予口服阿法骨化醇胶囊0.5μg,每日1次;同时2组患者每天均服用钙剂600 mg,连续治疗6个月。测定治疗前后骨密度(BMD)、生化指标,采取VAS法评价治疗前后疼痛改善情况等。结果治疗后观察组的L2、L3、L4、股骨颈的骨密度值分别增加了3.61%、4.76%、3.66%和5.06%;观察组的骨密度值分别增加了3.57%、4.71%、3.61%和5.0%,2组间差异无统计学意义(p>0.05)。治疗后观察组改善疼痛症状优于对照组(p<0.05)。结论两种药物治疗老年性骨质疏松症具有良好的临床疗效,能显著增加患者骨密度,缓解疼痛程度;但阿仑膦酸钠片服药方便,患者顺从性较好,较适宜在临床推广应用。

Objective To compare clinical efficacy and safety of alendronate sodium tablets and alfacalcidol capsules treatment of senile osteoporosis. Methods 56 senile patients with osteoporosis were randomly divided into two groups. The observation group received oral alendronate sodium tablets 70 mg, once a week; and the control group received oral alfacalcidol capsules 0. 5 μg daily; at the same time all patients were taking calcium 600 mg dai- ly, continuous treatment for 6 months. Bone mineral density （ BMD）, biochemical parameters were measured and taking VAS pain evaluation method to improve the situation. Results After treatment L2, L3 , L4 and femoral neck BMD of observation group increased by 3.61%, 4. 76%, 3.66% and 5.06% ; and that of observation group increased were 3.57% , 4. 71% , 3.61% and 5.0%, the difference between the two groups was not statistically significant （p 〉0.05）. Observation group improvements in pain symptoms better than the control group after treatment（p 〈 0. 05）. Conclusion Both drugs treatment of senile osteoporosis had good clinical efficacy, can significantly increase bone mineral density, relieve pain; but taking alendronate sodium tablets convenient, patient compliance is better, maybe more appropriate to the clinical application.