托烷司琼加镇静剂对减轻乳腺癌化疗所致恶心呕吐的效果评价

Efficacy of tropisetron and tranquilizer in reducing breast cancer chemotherapy- induced nauseaand vomiting

目的观察托烷司琼加镇静剂对预防乳腺癌化疗所致恶心呕吐的效果。方法将78例乳腺癌化疗患者随机分成单药组40例和复药组38例，单药组单用静脉滴注托烷司琼的止吐方法，复药组采用静脉滴注托烷司琼加肌肉注射氯丙嗪的止吐方法，观察2组恶心、呕吐发生情况d结果单药组恶心呕吐发生率显著高于复药组，2组不良反应发生率比较差异无统计学意义。结论静脉滴注托烷司琼加肌肉注射氯丙嗪的止吐方法可以减少乳腺癌化疗所致的恶心、呕吐，此方案值得推广。

Objective To observe the effect of tropisetron and tranquilizer on preventing nausea and vomiting induced by breast cancer chemotherapy, in comparison with using only tropisetron. Methods 78 cases of breast cancer patients undergoing chemotherapy were randomly divided into the observation group （40 cases） and the control group （38 cases）. The observation group used the method of antiemetic intravenous tropisetron, while the control group adopted intravenous drip of tropisetron combined with intramuscular injection of chlorpremazine. The incidence of nausea and vomiting of two groups was observed. Results The incidence of nausea and vomiting of the observation group was higher than that of the control group. The incidence of adverse reaction showed no obvious difference between two groups. Conclusions Intravenous injection of tropisetron combined with intramuscular injection of chlorpromazine can reduce nausea and vomiting caused by chemotherapy of breast cancer, so this method is worthy of popularization.