CsOH/DMSO促进下卤代芳烃与酚的反应:一种合成二芳基醚的简便方法

CsOH/DMSO Promoted Reactions of Aryl Halides with Phenols: A Convenient Method for the Synthesis of Diaryl Ethers

在氢氧化铯/二甲基亚砜(CsOH/DMSO)碱体系促进下,卤代芳烃与酚可在加热条件下直接反应,生成二芳基醚.该反应无需使用过渡金属催化剂和配体,亦无需惰性气体保护,是一种简洁的绿色合成方法.基于一系列实验结果,我们提出了经由苯炔进行的反应机理.

The reactions of aryl halides with phenols promoted by CsOH/dimethyl sulfoxide （CsOH/DMSO） led to diaryl ethers. This method was free of transition metal catalysts and ligands, and could be performed without inert gas protection. Therefore, it was a concise and green synthetic method. Based on the experimental results, a mechanism involving the benzyne intermediates is supposed.