香豆素并[4,3-b]吡喃-4-酮类衍生物的有效合成方法

Synthesis of Coumarino[4,3-b]pyran-4-one Derivatives

在哌啶和聚乙二醇-400的作用下,通过3-乙酰基-4-羟基香豆素与芳香醛的缩合反应,合成了3-肉桂酰基-4-羟基香豆素,接着在I2-DMSO氧化体系下,成功制备了一系列香豆素并[4,3-b]吡喃-4-酮衍生物.该反应操作简单、条件温和、收率良好.产物结构经NMR,IR,MS及元素分析数据得以证实.

An efficient and easy method for the synthesis of coumarino[4,3-b]pyran-4-one derivatives underwent oxidative cyclization of 3-cinnamoyl-4-hydroxycoumarins, synthesized from condensation between 3-acetyl-4-hydroxycoumarin and aromatic aldehydes in the presence of piperidine and PEG-400 by using iodine in DMSO, has been described. All of above compounds have been confirmed by NMR, IR, MS spectra and elemental analysis.