摘要
在哌啶和聚乙二醇-400的作用下,通过3-乙酰基-4-羟基香豆素与芳香醛的缩合反应,合成了3-肉桂酰基-4-羟基香豆素,接着在I2-DMSO氧化体系下,成功制备了一系列香豆素并[4,3-b]吡喃-4-酮衍生物.该反应操作简单、条件温和、收率良好.产物结构经NMR,IR,MS及元素分析数据得以证实.
An efficient and easy method for the synthesis of coumarino[4,3-b]pyran-4-one derivatives underwent oxidative cyclization of 3-cinnamoyl-4-hydroxycoumarins, synthesized from condensation between 3-acetyl-4-hydroxycoumarin and aromatic aldehydes in the presence of piperidine and PEG-400 by using iodine in DMSO, has been described. All of above compounds have been confirmed by NMR, IR, MS spectra and elemental analysis.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2014年第1期204-209,共6页
Chinese Journal of Organic Chemistry