内脂素与妊娠期糖尿病相关性研究

Correlation study of visfatin and gestational diabetes mellitus

目的:通过测定妊娠期糖尿病孕妇的内脂素表达水平,探讨内脂素与孕期糖尿病间关系。方法:随机选取2011年06月至2012年6月在无锡市第四人民医院足月分娩且具备完整产前检查的初产妇共60例,其中30例为妊娠糖尿病者,30例为正常对照组。所有选取的孕妇均详细记录基本信息,并留取母体孕晚期空腹血检测血糖、胰岛素、血脂水平,并计算胰岛素抵抗指数、孕晚期体重指数,测定母体孕晚期空腹血内脂素表达水平。结果:与对照组比较,妊娠期糖尿病组空腹血糖、空腹胰岛素、孕期体重增加值、甘油三酯、胰岛素抵抗指数及孕晚期BMI明显升高,差异均有统计学意义(P<0.05)。妊娠期糖尿病组的胆固醇水平略高于对照组,但差异无统计学意义(P>0.05)。结论:妊娠期糖尿病组母血内脂素水平明显升高,提示内脂素可能参与了妊娠期糖尿病的发病过程。

AIM： To explore the relationship between visfatin and gestational diabetes mellitus by detecting the level of visfatin in gestational diabetes mellitus patients. METHODS： 60 primiparae patients with singleton birth were randomly selected from the forth people＇s hospital of wuxi from June of 2011 to June of 2012 and were individed into gestational diabetes mellitus group and control group （each group n = 30）. The essential information of all patients were recorded and the levels of fasting plasma glucose, fasting insuline, blood fat （cholesterol and triglyceride）, visfatin were detected, and the insulin resistance index and BMI were calculated. RESULTS： Compared to the control group, the levels of the fasting plasma glucose, fasting plasma insulin, maternal weight gain, triglyceride,the insulin resistance index and the BMI of prior to delivery were increased significantly in gestation diabetes rnellitus group,there were statistically significant difference （P〈0.05）. Compared to the control group, the level of cholesterol was increased, but there was no statistically significant difference （ P 〉 0.05 ）. CONCLUSION. The maternal level of visfatin are increased in gestation diabetes mellitus, which suggests visfatin maybe involves in the pathogenic mechanism of gestation diabetes mellitus.