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新疆哈萨克族食管癌患者LRRFIP1基因甲基化及其与预后关系的研究 被引量:1

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摘要 目的探讨新疆哈萨克族食管癌(Esophageal Carcinoma,EC)患者LRRFIP1基因甲基化状态及其与食管癌发生及预后之间的关系。方法采用亚硫酸氢盐修饰联合限制性内切酶分析法(combined bisulfite restriction analysis,COBRA)检测哈萨克族共28例食管癌及癌旁组织标本LRRFIP1基因启动子区甲基化状况,建立Cox回归模型分析临床病理指标及LRRFIP1基因甲基化水平等因素与预后的关系。结果 28例哈族食管癌患者癌组织和癌旁正常组织的LRRFIP1基因启动子甲基化率分别为71.43%和46.43%,差异有统计学意义(P<0.05)。预后因素分析表明肿瘤浸润程度、TNM分期、淋巴结转移是影响哈族食管癌预后的独立危险因素。结论 LRRFIP1基因启动子区甲基化状态与新疆哈族食管癌的发生有密切的关系,但可能与食管癌预后无关。
出处 《毒理学杂志》 CAS CSCD 北大核心 2013年第6期438-441,共4页 Journal of Toxicology
基金 国家自然科学基金(81060240)
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