利用VBM技术测量轻微型肝性脑病患者全脑灰质体积的变化

Voxel-Based Morphometry Analysis of Whole Brain Gray Matter Volume Change in Patients with Minimal Hepatic Encephalopathy

目的利用优化的基于体素的形态学方法(VBM)分析轻微型肝性脑病(MHE)患者全脑灰质体积变化的特点。方法 16例MHE患者及17名正常人,用3.0 T磁共振对其进行高分辨率三维T1WI扫描,利用VBM软件对扫描获得的图像进行处理。运用VBM对MHE组和对照组的全脑灰质体积变化进行统计学分析。结果MHE患者与对照组相比双侧小脑后叶、双侧豆状核、双侧颞中回、双侧中央后回、双侧海马、右侧舌回、左侧苍白球、左侧前扣带回、左楔叶等区域的灰质体积下降,双侧丘脑、双侧脑干灰质体积有所增加[P<0.05(AlphaSim校正)]。结论 VBM技术能够显示MHE患者全脑灰质的改变,对早期诊断MHE及探究其发病机制具有重要的应用价值。

Objective To compare the grey matter changes between patient with minimal hepatic encephalopathy and normal people by optimized voxel - based morphometry. Methods 16 patient with MHE and 17 healthy volunteers as con- trol were recruited in the study. To acquired the images by high -resolution volumetric T1 -weighted images and analyzed data by VBM toolbox of SPM5. Results The volume of the bilateral lentiform nucleus, middle temporal gyrus, postcentral gyrus, cerebellum posterior lobe, hippocampus, fight lingual gyrus, left globus pallidus, left anterior cingulate, left cune- us,thalumi, brainstem, in MHE patients group was difference with healthy control group [ P 〈 0. 05 （AlphaSim） ]. Conclusion VBM can reveal volumetric changes of gray matter in MHE patients, which is a profound influence upon MHE clinical study in terms of the early diagnosis of MHE and its pathogenic mechanism.