HIV感染者的固定性伴服用抗病毒药物预防艾滋病临床试验参与意愿研究

Analysis of willingness to participate in clinical trials using antiviral drugs for HIV prevention among those with HIV-infected regular sexual partners

目的了解我国四川、新疆两地HIV感染者的固定性伴(HIV-negative regular sexual partners,PARs)服用抗病毒药物预防艾滋病临床试验参与意愿及影响因素。方法通过横断面调查的方法,采用单因素和多因素Logistic回归进行影响因素分析。结果本研究共纳入396名PARs,其中仅12.88%的PARs听说过药物预防措施,经调查员讲解后,愿意参与临床试验的占85.86%。多因素分析结果显示,参与意愿的影响因素为户口(农村/城市:AOR=4.269,P=0.000 5);自认为感染艾滋病的可能性(大/小:AOR=2.509,P=0.022 1;一般/小:AOR=2.338,P=0.048 4);近半年,最近1次与阳性性伴发生性行为时安全套使用情况(发生性行为未使用安全套/未发生性行为:AOR=10.451,P=0.029 4);阳性性伴的用药态度(支持/不太清楚及反对:AOR=2.079,P=0.042 9)。结论 PARs临床试验参与意愿较高,参与意愿受户口、自身风险认知以及社会支持的影响。

Objective To investigate the willingness and its influencing factors to participate in the clinical trials which take antiviral drugs to prevent HIV among the HIV-negative persons whose regular sexual partners were HIV-infected persons （PARs） in Siehuan and Xinjiang, China. Methods A cross-sectional survey was conducted and influencing factors were analyzed by univariate and multivariate logistic regression. Results Totally 396 qualified subjects were recruited, of which 12.88% had ever heard and 85.86% were willing to participate in the clinical trials of HIV prevention. Household registration （rural/urban： AOR =4. 269, P =0. 000 5）, self-awareness of HIV infection risk （high/low： AOR =2. 509, P =0. 022 1 ; moderate/low： AOR = 2. 338, P =0. 048 4 ）, using condoms or not when having sex with HIV-infected partners in the nearly six months （not using/not having sex： AOR = 10.451, P =0. 029 4）, and attitude to HIV-infected partners to medication （ support/not support or unsure.. AOR = 2. 079, P = 0. 042 9 ） were screened by multivariate analysis. Conclusion The willingness is relatively high, which is affected by household registration, self-risk cognition and soeial support.