鼻用激素对OSAHS患者治疗前后nCPAP压力值的比较研究

The effect of nasal cortisteroids on the effective pressure value of nCPAP for patients with OSAHS

目的观察鼻用激素对OSAHS患者治疗前后nCPAP压力值的影响。方法 31例经PSG诊断为中重度OSAHS的患者,应用鼻用激素治疗14天,并在鼻用激素治疗前后连续2个夜晚使用nCPAP,比较分析鼻用激素治疗前后nCPAP的90%有效使用压力值。结果所有患者使用nCPAPs的90%有效压力值,由治疗前的平均9.710±2.7073cmH_2O降至治疗后的8.519±2.5184cmH_2O(P=0.000)。结论鼻用激素能够降低OSAHS患者使用nCPAP的有效压力值,有望提高患者对nCPAP治疗的依从性。

Objective To observe the changes in necessary pressure value of nCPAP before and after the use of nasal cortisteroids for patients with OSAHS. Method Included in this study were 31 patients diagnosed as moderate to severe degrees of OSAHS by PSG. They were given a course of nasal cotristeroids therapy for 14 days. Meanwhile, all these cases accepted nCPAP treatment two nights continuously, given before and after nasal cotristeroids therapy respectively. Then, a comparative analysis was made on the difference in 90% effective treatment pressure value of nCPAP given before and after the use of nasal cortisteroids therapy. Result In this group of cases, the mean value of 90% effective treatment pressure with the use of nCPAP was 9.710±2.7073 cmH20 before nasal cotristeroids therapy, while it was redued to 8.519±2.5184 cmH20 following the treatment of nasal therapy, with a significantly statistical difference between them （P=0.000）. Conclusion Nasal cortisteroids therapy may decrease the effective treatment pressure value of nCPAP used for cases with OSAHS. Therefore, the compliance of patients should be improved through such an effect on the use of nCPAP.