血浆D-二聚体与食管鳞癌临床病理学特征的相关性

Correlation between plasma D-dimer levels and clinicopathologic characteristics of esophageal squamous cell carcinoma

目的:通过对食管鳞癌患者术前血浆D-二聚体水平和术后病理T、N分期的相关性做回顾性分析,探讨血浆D-二聚体水平与食管鳞癌恶性程度的关系。方法:选取本院2009年10月至2010年6月间101例无血液系统异常的食管鳞癌患者,对其术前血浆D-二聚体水平,术后病理T、N分期,组织学分级、转移N个数、肿瘤位置、肿瘤长径,病理分期等做统计学分析,探讨血浆D-二聚体水平与肿瘤转移、侵袭的关系。结果:术前血浆D-二聚体水平与病理组织学分级、肿瘤长径的相关性均无统计学意义(P>0.05);而与T、N、TNM分期成正相关(P<0.05),并与阳性淋巴结枚数呈显著正相关(P<0.01)。此外,胸下段食管鳞癌患者术前血浆D-二聚体水平高于胸中上段者。结论:食管鳞癌患者D-二聚体水平与T、N、TNM分期、阳性淋巴结枚数成正相关,具有重要的临床意义。

Objective：To determine the relationship among tumor malignancy, invasion, and plasma D-dimer （DD） levels via a retrospective analysis of the correlation between preoperative plasma DD levels and postoperative pathology parameters in esophageal cancer patients. Methods：A total of101 esophageal cancer patients without coagulation among preoperative plasma DD levels and postoperative pathology parameters in esophageal cancer patients who underwent radical operation between January 2009to April 2010 were enrolled. The preoperative plasma DD levels, postoperative pathology T, N Grade, number of metastatic lymph nodes, tumor posi-tion, tumor length, and TNM stage were recorded. A statistic analysis of the above parameters was performed to reveal the correlation between plasma DD levels and tumor pathology features.Results： Preoperative plasma DD level has no correlation with Grade and tu-mor length, but shows positive correlation with pathology T, N status, and TNM stage, and has strong positive correlation with numbers of metastatic nodes. In addition, lower-third thoracic esophageal cancer patients have higher DD level than middle-third thoracic cases. Conclusion：Plasma DD level has a positive correlation with T stage, N stage, TNM stage, and number of positive lymph nodes. It also has important clinical significance.