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microRNA在胃癌中的生物学作用 被引量：10

Biological role of microRNAs in gastric cancer
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摘要 microRNA(miRNA)是一类含量丰富且高度保守的非编码小RNA分子,调控细胞分裂、分化、调亡等重要的生物学过程,并且在很多疾病中表达失调。miRNA在多种肿瘤的发生、发展中发挥重要作用。目前,对miRNA的研究正逐步从肿瘤分子研究走向临床应用领域,作为生物标志物用于癌症的诊断以及作为靶分子用于治疗已逐渐得到确认。本文对miRNA在胃癌中作为一个潜在的生物标志物用于诊断、预后、药物反应以及易感性的预测等方面的潜能进行综述。 MicroRNAs （miRNA） are a class of small non-coding RNA molecules that are rich in content and are highly con-served. miRNA can regulate vital biological processes, including cell division, differentiation, and cell apoptosis. Their expression is dysregulated in many diseases. miRNA are essential in the initiation and development of various cancers. Recent miRNA studies have gradually moved from basic molecular studies of cancer onto areas of clinical application. The use of miRNA as biomarkers for cancer diagnosis and target molecules for cancer treatment is increasingly being identified. This review summarizes the potential applications of miRNA as biomarkers for diagnosis and prognosis of gastric cancer, drug response, and susceptibility prediction.
作者 唐云云 唐海林 苏琦
机构地区 南华大学肿瘤研究所
出处 《中国肿瘤临床》 CAS CSCD 北大核心 2014年第2期131-133,共3页 Chinese Journal of Clinical Oncology
基金 国家自然科学基金项目(编号:31100935 81102854 81374013)资助~~
关键词 胃癌 微小RNA 生物标志物 诊断 预后 gastric cancer, miRNA, biomarker, diagnosis, prognosis
分类号 R735.2 [医药卫生—肿瘤]
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参考文献26

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同被引文献76

  • 1黄宏星.多西他赛用于肺癌、头颈部肿瘤和乳腺癌的研究结果公布[J].中国医药导刊,2006,8(4):311-312. 被引量：8
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  • 6Akhavantabasi S, Sapmaz A, Tuna S, et al. MiR-125b tar- gets ARID3B in breast cancer cells [J]. Cell Struct Funct, 2012,37(1) .. 27-38.
  • 7Saito M,Schetter AJ, Mo|lerup S, e al . The association of microRNA expression with prognosis and progression in ear- ly-stage,non-small cell lung adenocarcinoma: a retrospective analysis of three cohorts [J]. CAin Cancer Res, 2011,17(7) : 1875-1882.
  • 8Pallante P, Visone R, Croce CM, et al . Deregulation of mi- croRNA expression in follicular-cell-derived human thyroid carcinomas[-J]. Endocr Relat Cancer, 2010, 17 : Fgl-F104.
  • 9Chou CK, Chen RF, Chou FF, et al . miR-146b is highly ex- pressed in adult papillary thyroid carcinomas with high risk features including extrathyroidat invasion and the BRAF (V600E) mutation[J]. Thyroid, 2010,20: 489-494.
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引证文献10

二级引证文献11

中国肿瘤临床
2014年 第2期

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