结肠癌肝转移物理消融治疗的新进展

Progress in the thermoablation of colon cancer with liver metastasis

物理消融治疗是一种局部治疗,它可以有效地原位破坏结肠癌肝转移病灶,同时保留周围正常肝组织。与手术相比,消融治疗创伤较小、易于开展且可以重复。对于不能切除的结肠癌肝转移患者有较好的局部控制,对于肝功能较差或存在严重合并症的患者可以作为替代治疗。它可以人为地增大手术切缘,增加手术切除率。当结合肝切除时可以清除肝多发病灶和外科手术不能切除的病灶。消融治疗的主要限制在于局部复发和治疗相关并发症,将其作为多学科治疗的一部分可以提高治疗效果。

Thermoablation is a local treatment effectively used to prevent metastasis of colon cancer in the liver and can retain peripheral normal liver tissues. Ablation therapy is less invasive, easier to use, and more repeatable than surgery. This form of therapy also allows the local control of unresectable diseases. Furthermore, thermoablation can be applied as an alternative therapy for small re -sectable lesions in patients who manifest insufficient hepatic function after surgery or those with severe complications. Ablation therapy can artificially increase the surgical margin, thereby increasing the resection rate in patients. Multiple lesions in the liver and surgically inaccessible or unresectable diseases can also be removed. However, several limitations, including the local recurrence of the disease and treatment-related complications in patients, are also observed. The treatment outcome of thermoablation therapy can be further im -proved because this technique is used as a part of multimodality treatment.