星形细胞上调基因-1的研究进展

Progress on elevated gene-1 in astrocyte

星形细胞上调基因-1(AEG-1)在多种恶性肿瘤中显著高表达,在肿瘤的发生、增殖、血管生成、抗凋亡、侵袭转移及抗药性等多方面发挥重要作用,还参与炎性反应和自然免疫过程。研究表明AEG-1与PI3K/Akt、NF-κB、Wnt/β-catenin等多种信号通路相关,同时参与RNA诱导沉默复合体介导的基因沉默。因此,AEG-1有望成为肿瘤靶向治疗的新靶点。

Recently,it has found that the expression of astrocyte elevated gene-1（AEG-1） is elevated in subsets of various malignant cells. AEG-1 plays a potential role in several crucial aspects of oncogenesis,including cancer cell surviving,tumor progression,angiogenesis,antiapoptosis,invasion,metastasis and chemoresistance. Meanwhile,it has close relationship with inflammation and natural immunity. AEG-1 functions as a mediator of several signal path-ways PI3K / Akt,NF-κB,Wnt/β-catenin. Moreover,AEG-1 participates in RNA-induced silencing complex media-ting gene silencing. Therefore,AEG-1 may be a potential farget for clinical diagnosis and a nticancer medication.