摘要
肺纤维是一种高致死率的难治性疾病,TGF-β1可激活并上调NOX4 mRNA的表达,继而诱导机体产生大量ROS,而ROS可进一步激活Smad,参与介导TGF-β1/Smad信号通路,最终促使肺纤维化的发生。而通过各种技术手段阻断NOX4基因表达可干扰TGF-β1/Smad信号通路从而阻断肺纤维化,所以NOX4可能是肺纤维化进程中最具有前景的治疗靶点。
Pulmonary fibrosis is a refractory disease with high mortality. The expression of NOX4 mRNA can be ac-tivated and increased by TGF-beta1 which induces the production of a large number of ROS. ROS may further acti-vate Smad which involved in mediating the signaling pathway of TGF-β1 / Smad leading to the occurrence of pulmo-nary fibrosis. Blocking the expression of NOX4 gene may interfere the signaling pathway of TGF-β1 / Smad which may block the progress of pulmonary fibrosis. Therefore NOX4 may be the most promising therapeutic target in the process of pulmonary fibrosis.
出处
《基础医学与临床》
CSCD
北大核心
2014年第1期130-133,共4页
Basic and Clinical Medicine
基金
南京军区南京总医院青年基金(2011029)
