胃食管反流病症状谱及危险因素

Symptom spectrum and risk factors of gastroesophageal reflux disease

目的:探讨胃食管反流病(gastroesophageal reflux disease,GERD)症状谱,分析与之相关的危险因素。方法:以南充市中心医院消化内科门诊及胃镜室确诊的GERD患者为病例组,以健康体检者及无烧心、反酸等典型症状且内镜检查为慢性浅表性胃炎者为对照组,采用问卷调查收集GERD患者就诊的主要症状,分析GERD的相关症状谱及危险因素。结果:共收集病例组370例,对照组347例。GERD症状谱系广泛、多样化,临床表现以烧心、反流症状为主,分别占84.05%和70.00%;RE组与NERD组患者主要相关症状发生率比较差异无统计学意义(P>0.05)。低教育水平、吸烟、喜高脂食物、便秘、肥胖、食管裂孔疝等可能是GERD的危险因素。结论:GERD以烧心、反流为主要表现,RE与NERD临床表现相似,吸烟等多种危险因素与GERD发病有关。

Objective：To investigate symptom spectrum and risk factors of gastroesophageal reflux disease （GERD）. Methods：The patients with GERD confirmed and diagnosed by the clinic and endoscopy room in Nanchong Central Hospital were chosen as subjects, while the healthy individuals and the patients without heartburn, regurgitation but chronic superficial gastritis showed by endoscopic ex- amination were chosen as control group. Collect the main symptoms, and analyze symptoms spectrum and risk factors of GERD by re-search papers. Results：370 cases of subjects and 347 cases of control group had been collected. GERD symptom spectrums were broad and varied,and the clinical manifestations were heartburn and regurgitation which accounts for 84.05% and 70. 00% respectively. There was no significant difference of the incidence rate of the major associated symptoms between the RE and the NERD patients （ P 〉 0.05）. Low education level, smoking, eating greasy, constipation, obesity and esophageal hiatal hernia could be the risk factors of GERD. Conclusion：Heartburn and regurgitation were the main performances of GERD, and the RE and NERD patients had similar clinical presentations. The risk factors such as smoking may be associated with GERD.