超声检测模拟失重对男性志愿者上下肢血管内皮功能的影响

Study on the effect of simulated weightlessness on male's vascular endothelial function with ultrasound

目的探讨模拟失重对男性肱动脉和腘动脉血流介导的血管内皮功能的影响。方法男性志愿者22例,头低位持续卧-6°倾斜床模拟失重状态,持续45 d,应用高频超声于不同时间点检测血流介导的动脉血管内皮功能。结果模拟失重试验各检测时间点的肱动脉、腘动脉其收缩期及舒张期内径变化率比较差异无统计学意义。模拟失重过程中,肱动脉血流介导的内皮依赖性舒张功能较模拟失重前基础状态增高,且增高幅度随时间渐行下降,在模拟失重结束后第3天,则已低于基础状态水平,两者比较差异无统计学意义;腘动脉血流介导的内皮依赖性舒张功能较模拟失重前基础状态增高,且增高幅度随时间逐渐上升,在结束模拟失重后第3天,则已低于模拟失重过程,但仍高于基础状态水平,两者比较差异无统计学意义。结论模拟失重尚未对正常男性肱动脉和腘动脉血流介导的血管内皮功能构成明显影响。

Objectives To explore the effect of simulated weightlessness on male volunteers＇ flow-mediated vascular endothelial function of braehial artery and popliteal artery. Methods Twenty-two male volunteers were involved in this study. Weightlessness condition was simulated by continuous -6 degree head down tih bed rest and lasted for 45 d. Vascular endothelial function was examined by ultrasound on schedule. Results Flow-mediated vascular endothelial function of brachial artery increased during simulated weightlessness,but the increasing amplitude decreased gradually, then decreased after simulated weightlessness. Flow-mediated vascular endothelial function of popliteal artery increased during simulated weightlessness,and the amplitude increased gradually,then decreased after simulated weightlessness. The amplitude after weightlessness was larger than before. But no significance difference between these changes was found. Conclusion Flow mediated vascular endothelial function of brachial artery and popliteal artery of male volunteers was stable during simulated weightlessness, which indicated that simulated weightlessness had no significant effects on flow-mediated vascular endothelial function of brachial artery and popliteal artery.