818例肝血管瘤流行病学及临床特点分析

Analysis on Epidemiological and Clinical Characteristics of 818 Cases of Hepatic Hemangioma

目的探讨肝血管瘤患者的流行病学及临床特点。方法对广西医科大学第一附属医院东院及西院2003～2011年9年期间收治的肝血管瘤患者的临床资料进行回顾性调查，分析其流行病学及临床特点。结果共818例肝血管瘤患者纳入分析，其中男398例（48．7％），女420例（51．3％）。各年男女患者构成比差异无统计学意义（χ2=9．912，P=0．271），但不同年龄组的性别分布差异有统计学意义（χ2=18．791，P=0．0001），大于60岁年龄组中男性多于女性。肝血管瘤无特殊临床表现，本组病例中有75例（9．2％）患者合并有自身免疫性疾病。本组患者的肝血管瘤直径为0．5～39．0cm，中位直径为3．0cm，肿瘤大小与患者性别有关（P〈0．05），女性大于男性患者。肿瘤发生部位以肝右叶最常见，占57．2％，肿瘤发生部位在不同性别的分布差异无统计学意义（P〉0．05）。肝血管瘤以单发病灶最常见（70．0％），单发病灶中右叶病灶多于左叶病灶，多发病灶以双叶多发最常见。结论肝血管瘤在性别、年龄、肿瘤大小、位置等方面具有一定的分布规律，应深入开展防治策略研究；对参与肝血管瘤发生、发展的相关因素有待深入研究；自身免疫性疾病与肝血管瘤的关系值得进一步探讨。

Objective To explore the epidemiological and clinical features of hepatic hemangioma. Methods The clinical data of patients with hepatic hemangioma who were diagnosed in the First Affiliated Hospital of Guangxi Medical University from 2003 to 2011 were retrospectively analyzed, and then analyzed the epidemiological and clinical characteristics of hepatic hemangioma. Results Eight hundreds and eighteen patients with hepatic hemangioma were included in the study. Among them, 398 cases （48.7%） were male, 420 cases （51.3%） were female, and there were no significant differences in constitute of gender for each year （χ2=9. 912, P=0. 271）, but there were significant differences in constitute of gender between different age groups （χ 2= 18.791, P=0. 000 1）, male patients were more than female in the group of aged over 60 years old. There was no special clinical manifestations of hepatic hemangioma. There were 75 patients （9. 2%） combined autoimmune diseases in this group. The size of hepatic hemangioma ranged from 0. 5-39. 0 cm, the median diameter was 3.0 cm. There were significant differences between different gender, the tumor size of female patients were larger than male＇s （P〈0. 05）. The tumor happened mostly in the right hepatic lobe （57.2%）, and there were no significant differences of the tumor location in different gender （P〉 0. 05）. Hepatic hemangioma with a single lesion was most common （70.0%）, and the right lobe lesions were more common than the left lobe lesions in single lesion group, multiple lesions in double lobes were most common in multiple lesion group. Conclusions Hepatic hemangioma has a certain distribution pattern in gender, age, size, position, and so on, further research in prevention and controlled strategy need to be carried out in the future. At the same time, more in-depth research in the related factors participatedin occurrence and development of hepatic hemangioma also need to be carried out, especially for the relationship between gender, age, autoimmune diseases, and hepatic hemangioma, which is worthy to be discussed.