水相中微波辐射下铜催化合成苯并噻唑衍生物

Copper-catalyzed Microwave-assisted Synthesis of Benzothiazoles Derivatives in Water

目的用微波辐射催化法在水相中合成苯并噻唑化合物。方法在150 W微波辐射条件下,以CuCl2和菲啰啉为催化剂,2-碘芳烃、芳醛和硫化钠在100℃水相中反应30min得到目标苯并噻唑化合物。结果合成得到9个相应的苯并噻唑化合物,均通过1 H NMR、13 C NMR和质谱确认结构,最高收率为94%。结论使用微波辐射法水相中合成目标产物,与传统方法相比,避免使用大量有机溶剂对环境造成污染,且具有时间短、收率高的优点。

Objective Benzothiazoles were synthesized under microwave irradiation in water . Methods A variety of 2-iodoanilines and aldehydes could be reacted with sodium sulfide to give the desired corresponding products in high yields in 100 ℃ water for 30 min using copper catalysts under microwave ir-radiation . Results We have developed an efficient protocol for benzothiazoles ,9 target compounds can be synthesized in good to excellent yields up to 94% , and all of them were further characterized by 1 H NMR ,13C NMR and MS analysis . Conclusion Synthesis of target benzothiazoles compounds under microwave irradiation in water has an advantage of short reaction time and higher the yields compared to the conventional method .