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SMG-1在肿瘤疾病中的研究价值及进展 被引量：2

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摘要 SMG-1(suppressor with morphogenetic effect on genitalia-1,SMG-1)是新发现的磷脂酰肌醇-3-激酶相关激酶(the phosphoinositide 3-kinase-related kinase,PIKKs)家族成员,因其参与无义介导的mRNA降解(nonsense-mediated mRNA decay,NMD)途径,在基因毒性应激反应中维持基因组稳定性,并参与细胞生长、增殖及凋亡等多个生物进程,因此被应用到肿瘤疾病的发病机制及治疗等相关研究中并取得显著成果。本文将对SMG-1在肿瘤疾病中的研究进展进行阐述。
作者 王庆光 许利剑
机构地区 南京医科大学第二附属医院普外科
出处 《医学研究杂志》 2014年第1期6-8,154,共4页 Journal of Medical Research
关键词 SMG-1 无义介导的mRNA降解 基因毒性应激反应 肿瘤
分类号 R73 [医药卫生—肿瘤]
  • 相关文献

参考文献16

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二级参考文献8

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共引文献5

同被引文献32

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医学研究杂志
2014年 第1期

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