脑梗死二级预防中阿司匹林抵抗患者脑血管事件发生的独立危险因素分析

Analysis of the Independent Risk Factors of Cerebral Infarction Patients with Aspirin Resistance Occurred in the Secondary Prevention of Cerebral Infarction

目的探讨脑梗死二级预防中阿司匹林抵抗（aspirin resistance，AR）患者脑血管事件发生的独立危险因素。方法选择400例脑梗死患者作为研究对象，于人院当日开始服用阿司匹林，于服用7～10天后分别检测患者血小板聚集率，筛选出AR患者及敏感患者，对患者随访至少6个月，观察筛选患者脑梗死、其他血管事件发生率，并使用Logistic回归分析AR、血管事件发生的独立危险因素和预后。结果400例脑梗死患者中AR者100例（25％），敏感者300例（75％）。其中AR组女性、糖尿病患者比例及血低密度脂蛋白（LDL）胆固醇水平均高于阿司匹林敏感组，Logistic统计学结果显示糖尿病、高LDL血症均为AR发生的独立危险因素。结论脑梗死二级预防中AR发生率高，AR是发生随访期血管事件、脑梗死复发的独立危险因素。

Objective To investigate the influence factors of aspirin resistance in patients with cerebral vascular in the secondary prevention of cerebral infarction occurred. Methods Totally 400 cerebral infarction patients were selected as the research object, which started taking aspirin on admission day. After 7 - 10d, the patients＇ platelet aggregation rate was detected to selected patients with AR or with sensitive. All patients were followed up for 6 months, to observe the incidence of cerebral infarction and other vascular events. Re- sults In 400 cases of cerebral infarction patients, 100 cases of AR（25% ） , 300 cases of sensitivity（75% ）. In AR group, the proportion of women,patients with diabetes,and patients with high blood LDL was higher than that of group aspirin sensitive group. Logistic statistical results showed that diabetes, high blood LDL were independent risk factors for AR happened. Conclusion The incidence of AR in pa- tients with cerebral infarction secondary prevention is high. AR is independent risk factors for follow - up cerebral vascular events and re- current cerebral infarction.