氨茶碱联合雾化吸入治疗对AECOPD患者的疗效及肺功能的影响

Efficacy of Aminophylline Combined with Inhalation Therapy for Patients with AECOPD and Effect on Pulmonary Function

目的探讨氨茶碱联合布地奈德、复方异丙托溴铵雾化吸入治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床疗效及对肺功能的影响。方法将100例患者按随机数字表法分为两组,每组50例,两组患者均给予吸氧、抗感染、化痰等常规治疗,对照组给予常规治疗加用口服氨茶碱片,治疗组在常规治疗基础上加口服氨茶碱片、布地奈德和复方异丙托溴铵雾化吸入,其中氨茶碱片每次0.1g,3次/日。布地奈德每次1mg、复方异丙托溴铵每次2.5ml,均为3次/日,经高氧驱动雾化,两组疗程均为10天。比较两组的疗效及治疗前后肺功能的变化情况。结果治疗组有效率高于对照组,差异有统计学意义(P<0.05),两组患者的肺功能指标FEV1(L)、FEV1占预计值(%)均较治疗前改善(P<0.05或P<0.01),但治疗组改善的幅度较对照组更明显(P<0.05)。结论口服氨茶碱联合布地奈德、复方异丙托溴铵雾化吸入能有效改善AECOPD患者临床症状及肺功能,且用药安全性较好,值得推广。

Objective To investigate the clinical efficaly of aminophylline combined with inhalation of budesonide and compound ipratroium bromide for patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD） and its effecton pulmonary function. Methods One hundred patients with AECOPD were equally randomized into two groups. On the basis of conventional treat- ment, the patients in treatment group were given aminophylline combined with inhalation of budesonide and compound ipratroium bromide, and those in the control group were treated with aminophylline tablets alone. The efficacy was evaluated ten days later. Results After treatment,clinical symptoms, pulmonary function were improved more in treatment group than those in control group. Conclusion Amin- ophylline combined with inhalation of budesonide and compound ipratroium bromide is effective and safe in treating the patients with AE- COPD.