慢性持续期哮喘患儿心肌酶谱变化的临床意义

Clinical Significance of Changes of Myocardial Enzyme Spectrum in Pediatric Asthma During Chronic Duration

目的观察慢性持续期哮喘患儿心肌酶谱变化，探讨其临床意义。方法对于2010年1月～2012年12月在笔者医院哮喘专病门诊就诊的238例慢性持续期哮喘患儿进行心肌酶谱检测，给予吸入皮质激素和（或）白三烯调节剂，于治疗后3、6个月观察其临床症状评分（C—ACT）、肺功能（FEV1）、心肌酶谱的变化，并取同期儿童保健门诊体验的健康儿童40例为对照。结果236例哮喘患儿心肌酶谱CK—MB、CK、LDH、AST较健康儿童有显著性差异（P〈0．05）。治疗后3、6个月随着患儿的临床症状评分、肺功能的好转，心肌酶谱亦明显好转（P〈0，05）。结论慢性持续期哮喘患儿中由于炎症持续存在，心肌细胞也可能受到损伤，心肌酶谱发生改变。进行规范治疗后，随着临床症状评分和肺功能的改善，心肌酶谱也出现改善。

Objective To observe the changes of myocardial enzyme spectrum in pediatric asthma during chronic duration and ex- plore its clinical significance. Methods During Janaury 2010 to December 2012, the myocardial enzyme spectrum was tested in 236 ca- ses of children with chronic asthma duration in our hospital. The patients were given standard treatment of inhaled corticosteroids and/or leukotriene regulator. After 3 months and 6 months treatment, the changes of clinical symptom scores （ C - ACT） , pulmonary function （FEVI） , myocardial enzyme spectrum were observed. Meanwhile, we selected 40 health children as controls at the same period. Results Compared with healthy children,236 cases of asthma myocardial enzyme spectrum of CK - MB, CK, LDH, AST had significant differ- ence （P 〈 0. 05）. After 3 months, 6 months treatment, the patients＇ clinical symptom scores, lung functions, myocardial enzyme spec- trum were improved obviously （ P 〈 0.05）. Conclusion Due to persistent inflammation in pediatric asthma during chronic duration, car- diac cells may also be damaged, myocardial enzymes were changed. After standard treatment, with the improvement of clinical symptom scores, pulmonary functions, myocardial enzyme spectrums were also improved.