HPV感染及IL-1β、IL-6、IL-13的表达与子宫颈癌临床相关性分析

Relationship between HPV infection,expression of IL-1β,IL-6,IL-13 and the developing of cervical cancer

目的探讨子宫颈癌组织中的人乳头瘤病毒(human papilloma virus,HPV)感染及IL-1β、IL-6、IL-13的表达与临床病理资料的相关性。方法选取76例子宫颈癌组织,采用组织芯片技术、免疫组织化学技术及统计学技术,对检测HPV、IL-1β、IL-6、IL-13的各个指标间进行比较分析。结果 HPV、IL-1β、IL-6、IL-13的高表达与子宫颈癌患者术前有无化疗有相关性(P<0.01),与其它的临床病理资料无相关性。结论子宫颈癌术前经过一段时间的化疗,不但能使肿瘤缩小,还能抑制炎症因子的表达,预防肿瘤的复发。

Objective To discuss the correlation of HPV infection in cervical carcinoma, ex- pression of IL-1β, IL-6, IL-13, and their clinicopathologic data. Methods Seventy-six sam- ples of cervical carcinoma which tissues were collected from the Third Affiliated Hospital of Harbin Medical University since March to September in 2012. Tissue microarray technology, immunohistochemical technique and statistic technology were adopted to make comparative analysis of indexes for HPV, IL-1β, IL-6 and IL-13. Results The high expression of HPV, IL-1β, IL-6 and IL-13 correlated with the existence of patients＇ preoperative chemotherapy （P 〈 0.05）, but had no correlation with other clinicopathologic data. Conclusion Chemotherapy for a period of time before cervical carcinoma operation can not only narrow the turnout, restrain the expression of inflammatory factor, but also prevent the relapse of turnout.