摘要
目的探讨血清25-羟基维生素D(25-hydroxyvitaminD,25(OH)D)及胰岛素样生长因子-1(isulin-like growthfactor-1,IGF.1)与骨密度(bone mineral density,BMD)的相关性。方法用双能X线骨密度仪测定88例老年人腰椎(L2-4)及左股骨颈BMD,根据WH01998年的推荐诊断标准分组:正常对照组(A1组)、低骨量组(A2组)、骨质疏松组(A3组),并测定血清25(OH)D、IGF-I浓度及钙(Ca)、磷(P)等,对实验数据进行统计学分析。结果A2、A3组血清25(OH)D、IGF-1水平明显低于A1组(P〈0.05)。A2、A3组受试者腰椎和股骨颈的BMD与血清25(OH)D、IGF-1水平均呈正相关(P〈0.01),与Ca、P无相关性(P〉0.05)。全部受试者中有76.1%血清25(OH)D不足或缺乏。结论血清25(OH)D、IGF-1水平与原发性骨质疏松患者骨量减少有关,而维生素D不足或缺乏较为普遍,骨量减少时维生素D的补充较为重要。
Objective To explore the relationship between serum 25-hydroxyvitamin D (25 (OH) D), insulin-like growth factor - 1 ( IGF-1 ) and bone mineral density ( BMD). Methods Serum 25 (OH) D, IGF-I, calcium (Ca) and phosphorus (P) were measured in 88 elder. BMD of lumbar vertebra and left femoral neck were examined by dual energy X-ray absorptiometry. Based on WHO (1998) diagnostic criteria, all the subjects were divided into 3 groups: normal control group (A1 group), low bone mass group (A2 group), and osteoporosis group (A3 group). Results Serum 25 (OH) D and IGF-1 levels in A2 group and A3 group were significantly lower compared to those in A1 group (P 〈 0. 05 ). Serum 25 (OH) D and IGF-1 levels were significantly and positively correlated with BMD of lumbar spine and femoral neck (P 〈 0. 01 ), and not correlated with Ca and P (P 〉 0. 05 ). Among all the subjects, 76. 1% had inadequate (insufficient or deficient) vitamin D status. Conclusion Serum 25 (OH)D and IGF-1 levels are associated with bone loss. Vitamin D insufficiency and deficiency is so common that vitamin D supplement is necessary when bone loss are exist.
出处
《哈尔滨医科大学学报》
CAS
北大核心
2013年第6期522-525,共4页
Journal of Harbin Medical University
基金
哈医大二院院博士基金(BS2011-09)