崇明地区高尿酸血症患病率及其危险因素的流行病学调查

Epidemiological survey of prevalence of hyperuricemia and its risk factors in adult population of Chongming District, Shanghai

目的明确崇明地区高尿酸血症的患病率及其相关危险因素。方法采用随机整群抽样方法，调查崇明城桥镇1928例居民的高尿酸血症患病情况，内容涉及问卷、体格检查、血糖、糖化血红蛋白、血脂、尿酸等生化检测，并分析高尿酸血症的相关危险因素。结果1928例居民完成调查，占崇明地区人口的0．274％，其中男582例，女1346例，年龄40～70（54．59±7．920）岁。高尿酸血症共58例，占3．01％（男5．67％，女1．86％），经年龄和性别标化后，崇明地区高尿酸血症患病率为2．83％。标化后男、女患病率比较差异有统计学意义（男5．12％，女1．9％，P〈0．05）。单因素分析显示高尿酸血症患者年龄、空腹血糖、餐后2h血糖、糖化血红蛋白、总胆固醇、甘油三酯、血压、腰围、臀围均显著高于非高尿酸血症患者（P〈0．01），高密度脂蛋白低于非高尿酸血症组（P〈0．01）。多元回归分析显示年龄、性别、甘油三酯与高尿酸血症密切相关。结论崇明地区高尿酸血症患病率低，年龄增长、性别及血脂代谢紊乱是高尿酸血症患病的危险因素。

Objective To investigate the prevalence and risk factors of hyperuricemia among adult residents in Chongming District, Shanghai. Methods A cross-sectional survey with multiple stage stratified cluster and random sampling was performed. All residents aged from 40 to 70 were invited to participate in this survey. Questionnaire, physical examination, serum lipid-profile, 75 g oral glucose tolerance test, and Uric acid were undertaken. Data analysis was performed with SPSS 13.0 for windows statistical package. Results A total of 1928 residents participated in the survey, which was 27. 40/10000 of the residents. Of the 1928 residents surveyed, 582 were males and 1346 were females. The mean age of the participants was （54. 59 ± 7. 920） years and ranged from 40 -70 years. Hyperuricemia was detected in 58 participants （3.01%）. The age and gender adjusted prevalence of hyperuricemia was 2. 83%. The standardized prevalence of hyperuricemia in males （5.21%） was higher obviously than that in females （1.9%） （ P 〈 0. 05 ）. Mean age, fasting plasma glucose （FPG）, 2 h plasma glucose （ 2 h PG）, glycosylated hemoglobin （ HbA1 C）, total cholesterol （ TC ）, triglyceride （ TG）, systolic blood pressure （ SBP）, diastolic blood pressure （DBP）, waistline, and hips in hyperuricemia were significantly higher than those in non-hyperuricemia group （all P 〈 0. 01 ）. Logistic regression analysis demonstrated that the prevalence of hyperuricemia was positively correlated with aging, gender, and dyslipidemia. Conclusions There was a low prevalence of hyperurieemia among adult residents in Chongming district, Shanghai. Aging, gender, and dyslipidemia were the risk factors of hyperurieemia.