小儿社区获得性肺炎的流行病学特点及PCT水平的临床研究分析

Clinical analysis of pediatric community acquired pneumonia epidemiology and PCT levels

目的探讨血清降钙素原和C-反应蛋白在小儿社区获得性肺炎中的诊断应用。方法选择2010年8月～2013年1月收治的54例CAP患儿为实验组，健康对照组54例，所有研究对象均抽取静脉血，用离心机离心后留取血清置于-20℃环境中，采用免疫化学发光法测降PCT，免疫散射比浊法测CRP。结果CAP患者血清PCT和CRP均显著高于健康对照组而大叶性肺炎组患儿PCT和CRP也明显高于支气管肺炎组。结论血清PCT在敏感性和特异性均显著优于CRP，能够为临床医生及早判断肺部感染类型，选择合适的抗菌药物提供准确可靠的依据。

Objective To investigate the differential diagnosis significance of serum procalcitonin （PCT） in Children with bacterial and viral infected community-acquired pneumonia （CAP）. Methods Serum CRP and PCT levels were measured by enzyme immunoassay and immunoluminometric assay respectively in 64 infants with CAP. Results Serum PCT and CRP were significantly higher in CAP group than in control group. Serum PCT and CRP in lobar pneumonia group were higher than those in bronehopneumonia group. Conclusions Serum PCT level is a better marker than CRP for the diagnosis of CAP in children, and can be used as a reliable indicator of the early diagnosis for clinicians and rational use of antibiotics.