盐敏感高血压患者血清非对称二甲基精氨酸和一氧化氮水平的研究

Study on serum antisymmetry diethylarginine and nitrogen monoxidum levels in patients with salt-sensitive hypertension

目的探讨盐敏感高血压患者血清非对称二甲基精氨酸(ADMA)和一氧化氮(NO)水平的变化,分析血清ADMA和NO与盐敏感高血压的关系及其临床意义。方法盐敏感高血压患者60例作为研究组,同期体检健康人群60例作为对照组,检测2组血清ADMA和NO含量。结果研究组患者血清ADMA、NO水平均显著高于对照组(P均<0.001);而且随着盐敏感高血压患者血压分级的增高,患者血清ADMA和NO水平呈上升趋势(P均<0.05)。结论盐敏感高血压患者血清ADMA水平升高,抑制一氧化氮合酶及NO的合成,促进盐敏感高血压的发生发展。

Objective It is to discuss the changes of serum antisymmetry diethylarginine （ADMA） and nitrogen monoxi- dum （NO） levels in patients with salt-sensitive hypertension, and illustrate the clinical meaning of ADMA and NO in salt-sen- sitive hypertension. Methods 60 patients with salt-sensitive hypertension were collected as study group, and 60 health physical examination people were also collected as control group. Their serum ADMA and NO levels were detected in both groups. Re- suits Serum ADMA and NO levels were significantly higher in the patients of study group than that of the ones of control group （P 〈0.001） ; and the levels presented in a rising tendency with increase of salt-sensitive hypertension grade （P 〈0.05）. Conclusion Serum ADMA and NO levels increased in patients with salt-sensitive hypertension, and inhibiting eNOS synthesis would result in release of NO, further promote the development of salt-sensitive hypertension.