蒿蓝感冒颗粒抗炎、镇痛、镇咳及解热作用研究

Study on the anti-inflammatory,analgesic,antitussive and antipyretic effects of Haolan ganmao granules

目的:研究蒿蓝感冒颗粒的抗炎、镇痛、镇咳及解热作用。方法:通过二甲苯致小鼠耳廓肿胀及小鼠腹腔毛细血管炎性渗出实验考察其抗炎作用。采用冰醋酸致小鼠扭体实验和小鼠热板致痛实验考察其镇痛作用。采用氨水引咳法及枸橼酸引咳法考察其镇咳作用。采用干酵母致大鼠发热模型考察其解热作用。结果:蒿蓝感冒颗粒(2.9,5.8,11.6 g/kg)对二甲苯诱发小鼠耳廓肿胀及冰醋酸所致小鼠腹腔毛细血管炎性渗出均有显著抑制作用;冰醋酸致小鼠扭体试验及热板致痛实验显示,蒿蓝感冒颗粒(5.8,11.6 g/kg)能减少冰醋酸致小鼠扭体反应次数并延长热板致小鼠疼痛痛阈值;蒿蓝感冒颗粒(5.8,11.6 g/kg)对氨水致小鼠咳嗽反应及枸橼酸致豚鼠咳嗽反应均有明显的抑制作用;蒿蓝感冒颗粒(5.8 g/kg)对干酵母引起的大鼠发热有一定的解热作用。结论:蒿蓝感冒颗粒具有良好的抗炎,镇痛,镇咳及解热作用。

Objective： To observe anti-inflammatory, analgesic, antitussive and anfipyrefic effect of Haolan ganmao granules. Methods： Using the dimethylbenzene on mice for ear swelling and capillary permeability test to investigate anti-inflammatory action. The analgesic effects were observed using the hot plate test and acetic acid writhing test in mice. Relieving cough caused by the irritation of ammonia water in mice and cough model induced by citric acid in guinea pigs were used to observe the antitussive action. The models of dry yeast-induced fevered rats was used to study the antipyretic effects. Results： Haolanganmao granules （2.9,5.8,11.6 g/kg） showed obvious inhibition of swelling degree by dimethylbenzene. In addition, Haolanganmao granules（5.8,11.6 g/kg）could effectively reduce the writhing reaction frequency induced by acetic acid and prolong the threshold time by hot-plate. Also Haolanganmao granules （5.8, 11.6 g/kg） can reduce mice cough frequency and the coughing number of guinea pigs induced by citric acid, it has obvious antitussive effect. Haolanganmao granules（5.8g/kg）have obvious antipyretie effect. Conclusion： It is suggested that Haolanganmao granules has evident effects of anti-inflammatory, analgesic, antitussive and antipyretic.