DNA甲基化在动脉粥样硬化进程中的作用

The Role of DNA Mathylation in Atherosclerosis

动脉粥样硬化是一种基因和环境共同作用导致的复杂疾病,DNA甲基化是一种重要的表观遗传修饰调控机制,由环境因素导致,并可通过有丝分裂遗传下去。目前已有研究表明,DNA甲基化在动脉粥样硬化疾病的发生发展过程中起到至关重要的作用。本文综述了DNA甲基化在动脉粥样硬化方面的研究进展。

Atherosclerosis is a complex disease caused by both genetic and environmental factors. DNA methylation is an important epigenetic mechanism that regulates gene expression, while the altered gene expression parttrens caused by environment can be passed on to the daughter cells. Rencent studies suggested that DNA methylation played a critical role in the development of atherosclerosis. This article provides a review of the relationship of the DNA methylation and atherosclerosis in the recent studies.