期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

MAT1基因在癌症疾病中的作用与应用研究 被引量：5

下载PDF
导出
摘要 癌症是以细胞周期调控机制紊乱导致细胞不断增殖的一类疾病.现代医学研究认为,癌症的发生与突变与受损的DNA连续异常分裂有关,携带有此类DNA的细胞不断增殖导致肿瘤发生.细胞周期蛋白依赖性激酶活化激酶（cyclin dependent kinase-activating kinase,CAK）在调节细胞生长、增殖和导致癌细胞形成过程中有重要作用.MAT1是CAK的组配因子之一,也是CAK的重要组成部分,MAT1在CAK调节细胞周期过程中起重要作用,在多数癌细胞中可见MAT1基因的过度表达现象.就目前的研究情况来说,MAT1基因与多种癌症的发展有关,可能参与到癌细胞的恶性增殖、转移等方面.恶性肿瘤的现代治疗方法不断进步,手段不断创新,从微创治疗已发展至基因水平的治疗,有望通过靶向基因疗法遏制癌细胞的发展,未来可能还会运用到癌症的预防方面.现针对MAT1基因在癌症疾病中的应用情况综述如下.
作者 杨庆 甘嘉亮 张小龙 郭云 唐卫中 刘小健
机构地区 广西医科大学第一附属医院结直肠肛门外科
出处 《微创医学》 2013年第6期734-736,705,共4页 Journal of Minimally Invasive Medicine
基金 广西自然科学基金(合同号:桂科自0728149)
关键词 MAT1基因 细胞周期蛋白依赖性激酶活化激酶(CAK) 细胞周期蛋白依赖性激酶(CDK) 癌症
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献24

  • 1Devault A,Martinez A-M,Fesquet D. MAT1 ('menage à trois′) a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK[J].{H}The EMBO Journal,1995,(20):5027-5036.
  • 2Liu Y,Wu C,Galaktionov K. p42,a novel cyclin-dependent kinase-activating kinase in mammalian cells[J].{H}The Journal of Biological Chemistry,2004,(06):4507-4514.
  • 3Gerber MR,Farrell A,Deshaies RJ. Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins[J].{H}Proceedings of the National Academy of Sciences(USA),1995,(10):4651-4655.
  • 4He QJ,Peng H,Collins SJ. Retinoid-modulated MAT1 ubiquitination and CAK activity[J].{H}FASEB JOURNAL,2004,(12):1734-1736.
  • 5Wang J,Barsky LW,Shum CH. Retinoid-induced G1 arrest and differentiation activation are associated with a switch to cyclin-dependent kinase-activating kinase hypophosphorylation of retinoic acid receptor alpha[J].{H}The Journal of Biological Chemistry,2002,(45):43369-43376.
  • 6Larochelle S,Chen J,Knights R. T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity[J].{H}The EMBO Journal,2001,(14):3749-3759.
  • 7Busso D,Keriel A,Sandrock B. Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities[J].{H}The Journal of Biological Chemistry,2000,(30):22815-22823.
  • 8Toh Y,Pencil SD,Nicolson GL. A novel candidate metastasis-associate gene,mat1,differentially expressed in highly metastatic mammary adenocarcinoma cell lines[J].{H}Biological Chemistry,1994,(37):22958-22963.
  • 9Talukder AH,Mishra SK,Mandal M. MTA1 interacts with MAT1,a cyclin-dependent kinase-activating kinase complex ring finger factor,and regulates estrogen receptor transactivation functions[J].{H}The Journal of Biological Chemistry,2003,(13):11676-11685.
  • 10Kaldis P,Solomon MJ. Analysis of CAK activities from human cells[J].{H}European Journal of Biochemistry,2000,(02):4213-4221.

二级参考文献68

  • 1刘建平,袁世珍.“分子开关”MAT1基因的研究进展[J].国外医学（生理病理科学与临床分册）,2004,24(4):306-308. 被引量：4
  • 2刘建平,袁世珍,张世能,詹俊,朱兆华.胰腺癌中MAT1蛋白的表达与其临床病理特征的关系[J].中国病理生理杂志,2005,21(1):163-166. 被引量：6
  • 3张世能,徐凤琴,黄志清,曾志勇,袁世珍.反义MAT1重组腺病毒对人胰腺癌细胞BxPC-3的周期调控作用[J].中华医学杂志,2005,85(19):1348-1351. 被引量：9
  • 4Wu L, Chen P, Shum CH, et al. MAT1 - modulated CAK activity regulates cell cycle G( 1 ) exit[ J ]. Mol Cell Biol,2001, 21(1): 260-270.
  • 5Kampmeier J, Behrens A, Wang Y, et al. Inhibition of rabbit keratocyte and human fetal lens epithelial cell proliferation by retrovirus- mediated transfer of antisense cyclin G1 and antisense MAT1 constructs[J]. Hum Gene Ther, 2000, 11(1): 1-8.
  • 6Wu L, Chen P, Hwang JJ, et al. RNA antisense abrogation of MAT1 induces G1 phase arrest and triggers apoptosis in aortic smooth muscle cells[J]. J Biol Chem, 1999, 274(9): 5564- 5572.
  • 7Rossi DJ, Londesborough A, Korsisaari N, et al. Inability to enter S phase and defective RNA polymerase Ⅱ CTD phosphorylation in mice lacking Mat1[J]. EMBO J, 2001, 20(11):2844 - 2856.
  • 8Talukder AH, Mishra SK, Mandal M, et al. MTA1 interacts with MAT1, a cyclin - dependent kinase - activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions[J]. J Biol Chem, 2003, 278(13):11676- 11685.
  • 9Ohkawa K, Ishida H, Nakanishi F, et al. Hepatitis C virus core functions as a suppressor of cyclin- dependent kinaseactivating kinase and impairs cell cycle progression[J]. J Biol Chem, 2004, 279(12): 11917- 11926.
  • 10Wang J, Barsky LW, Shum CH, et al. Retinoid - induced G1arrest and differentiation activation are associated with a switch to cyclin- dependent kinase- activating kinase hypophosphorylation of retinoic acid receptor alpha [ J ]. J Biol Chem,2002, 277(45): 43369 - 43376.

共引文献12

同被引文献24

引证文献5

二级引证文献6

微创医学
2013年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部