白细胞介素8-251A/T多态性与口腔鳞癌相关性研究

Association between interleukin-8-251A/T polymorphism and risk of oral squamous cell carcinoma

目的探讨白细胞介素8(IL-8)-251A/T多态性与口腔鳞癌的相关性。方法应用聚合酶链反应-限制性片段长度多态性方法检测193例对照组人群和167例口腔鳞癌患者IL-8-251A/T多态性。结果 IL-8-251A/T多态性AA基因型和A等位基因在口腔鳞癌组的频率分别为22.8%和45.5%,明显高于其在对照组中的频率,分别为10.9%和36.5%,两组相比,差异具有显著性(P<0.05)。未发现IL-8-251A/T多态性与性别、年龄、分化程度、临床分期和转移状态等临床特征具有明显的相关性(P>0.05)。结论 IL-8-251A/T多态性与口腔鳞癌发病相关,可能是易感基因之一。

【Objective】To investigate the association between IL-8-251A/T polymorphism and risk of oral squa- mous cell carcinoma（OSCC）. 【Methods】 Polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） method was used to analyze the IL-8-251A/T polymorphism in 193 healthy controls and 167 patients with OSCC.【Results】The frequencies of AA genotype and A allele of the IL-8-251A/T polymorphism were 22.8% and 45.5% in OSCC patients and 10.9% and 36.5% in healthy controls, respectively. The AA genotype and A allele were associated with a significantly increased risk of OSCC compared with the TT genotype and T allele（P 0.05）. After stratification analyses based on clinical features, no significant association was detected between the IL-8- 251A/T polymorphism and gender, age, differentiation status, clinical stages, and metastasis status（P 0.05）.【Con- clusions】IL-8-251A/T polymorphism is related to the development of OSCC, suggesting that IL-8 may be a sus- ceptibility gene for OSCC.