多囊卵巢与多囊卵巢综合征的超声特征和激素水平相关性分析

Correlation between ultrasound parameters and hormone level in patients with polycystic ovary and polycystic ovary syndrome

将超声诊断为卵巢多囊样改变的104例患者按临床症状及内分泌检查分为多囊卵巢综合征（PCOS）组与单纯卵巢多囊样改变（PCO）组,同时纳入有正常排卵的妇女40人,做对照组,分别测定其卵巢面积（TA）、髓质面积（SA）及二者的比值（SA/TA）,分析激素水平与SA/TA的相关性.PCO组的卵巢TA、SA及SA/TA、血清睾酮、苗勒氏管激素AMH及抑制素B均低于PCOS组,但高于对照组,差异具有统计学意义（P＜0.05）.PCOS患者血清睾酮水平与卵巢超声参数SA/TA有显著相关性（P＜0.05）.PCOS患者的AMH和抑制素B高于PCO组和对照组,说明AMH和抑制素B与卵巢多囊样改变的程度有关,可以用于鉴别PCOS和PCO.同时,SA/TA与PCOS血清睾酮升高有关,可以作为鉴别PCOS和PCO的内分泌指标.

A total of 104 patients with polycystic ovarian changes on ultrasound were divided into polycystic ovary syndrome （PCOS） and polycystic ovaries （PCO） groups according to their clinical symptoms and endocrine examinations. And 40 women with normal ovulation served as the controls. Ovarian volume （OV）, ovarian stroma area （SA）, ovarian total area （TA） and SA/TA ratio were measured by transvaginal ultrasonography. Their endocrine hormone levels were determined. Patients with PCOS showed significantly higher OV, SA, TA and SA/TA than those of PCO and control groups. SA/TA was positively correlated with testosterone. The median serum levels of anti-Mullerian hormone （AMH） and inhibit B in the PCO group were intermediate between those in control and PCOS groups. AMH and inhibin B of PCOS were higher than the PCO and control groups. It indicated that the levels of AMH and inhibit B were associated with the degree of polycystic ovaries and they could be used to differentiate PCOS and PCO. SA/TA is associated with the elevated serum testosterone of PCO. And SA/TA is an important ultrasonic parameter for diagnosing PCOS.